Saint Louis, Missouri
Root 66 Dispensary, Saint Louis, MO
On Missouri's license list as of Oct 14, 2026Root 66 Dispensary is a state-licensed adult-use and medical dispensary in Saint Louis, MO, open daily 8 AM to 12 AM.
6660 Manchester Ave, Saint Louis, MO 63139(314) 282-7978
Adult-use + Medical21+ with ID, or your medical card
Open lateMondays till 12 AM
Hours
| MondayLATE | 8 AM to 12 AM |
| TuesdayLATE | 8 AM to 12 AM |
| WednesdayLATE | 8 AM to 12 AM |
| ThursdayLATE | 8 AM to 12 AM |
| FridayLATE | 8 AM to 12 AM |
| SaturdayLATE | 8 AM to 12 AM |
| SundayLATE | 8 AM to 12 AM |
Hours from the store's Google listing, pulled Oct 15, 2026. Call ahead.
Questions
Is Root 66 Dispensary a licensed dispensary?
Missouri's license list shows Root 66 Dispensary with license DIS000036, status "Licensed". Checked against the list dated Oct 14, 2026.
Is Root 66 Dispensary adult-use or medical?
Both. Adults 21+ can shop with a valid photo ID, and medical patients can shop with their card.
What are Root 66 Dispensary hours?
Open daily 8 AM to 12 AM. Hours from the store's Google listing, pulled Oct 15, 2026. Call ahead.
What time does Root 66 Dispensary close?
It closes at 12 AM every day, per posted hours.
What time does Root 66 Dispensary open?
It opens at 8 AM every day, per posted hours.
Where is Root 66 Dispensary?
6660 Manchester Ave, Saint Louis, MO 63139. Call (314) 282-7978 for directions.
Location
6660 Manchester Ave, Saint Louis, MO 63139. Driving directions · Google listing
Before you go
- What to bring: a valid government photo ID. You must be 21 or older. First visit? Read first time at a dispensary.
- Purchase limit: 3 oz of flower or the equivalent per transaction: 24 g of concentrate or 2,400 mg of THC in edibles. They share one cap.
- Visiting from out of state: Yes. Anyone 21+ with a valid government photo ID. Every state's rule: can tourists buy weed.
- Legal adult-use sales began: February 3, 2023.
Source: Missouri's official regulator site. Rules change, so check with the store.
